NFkB p65 antibody | GeneTex GTX27970 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

NFkB p65 antibody

catalog :

GTX27970

quantity :

1.00 ml

price :

299 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 3

Reference
Ekström M, Halle M, Bjessmo S, Liska J, Kolak M, Fisher R, et al. Systemic inflammation activates the nuclear factor-kappaB regulatory pathway in adipose tissue. Am J Physiol Endocrinol Metab. 2010;299:E234-40 pubmed publisher
Merzianu M, Jiang L, Lin P, Wang X, Weber D, Vadhan-Raj S, et al. Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia and does not correlate with p65 NF-kappaB activation. Mod Pathol. 2006;19:891-8 pubmed
Halle M, Gabrielsen A, Paulsson-Berne G, Gahm C, Agardh H, Farnebo F, et al. Sustained inflammation due to nuclear factor-kappa B activation in irradiated human arteries. J Am Coll Cardiol. 2010;55:1227-36 pubmed publisher

product information

Catalog No :

GTX27970

Product Name :

NFkB p65 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

1.00 ml

List Price :

299 USD

list of Pubmed id :

20484010,16636680,20298930

Isotype :

IgG

Product Description :

Rabbit polyclonal to NFkB p65

CrossReactivity :

Hu, Ms, Rat

Background :

In resting cells, NFkB is retained in the cytoplasm bound to inhibitory proteins of the IkB family. Degradation of IkB proteins occurs with cell activation, via of variety of signals, including inflammatory cytokines and bacterial lipopolysaccharides (LPS) as well as oxidative and fluid mechanical stress. This results in nuclear translocation of NFkB and the transcriptional gene activation of pro-inflammatory genes (1,9). NFkB plays a role in the development of numerous pathological states. Activation of NFkB induces gene programs leading to transcription of factors that promote inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. It is also thought that there are some substances with possible anti-inflammatory effects that are also NFkappaB regulated. There is some evidence indicating NFkB as a key factor in the pathophysiology of cardiac ischemia-reperfusion injury as well as the development of insulin dependent Diabetes Mellitus (3-4).

Immunogen :

Synthetic peptide mapping to the carboxy terminus of human NFkB p65.

Buffer :

Phosphate-buffered saline containing 0.1% sodium azide and 0.2% gelatin

Uses :

IHC, IHC-P, IP, WB

Concentration :

0.2mg/ml

General References :

Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.