p21 Cip1 antibody | GeneTex GTX27960 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

p21 Cip1 antibody

catalog :

GTX27960

quantity :

1.00 ml

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation, immunohistochemistry - frozen section

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 5	Lee W, Jo S, Lee M, Won C, Lee M, Choi J, et al. The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo. Int J Mol Sci. 2016;17: pubmed publisher
	Lin K, Lin C, Kuo S, Lai J, Wang Y, You H, et al. Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma. Biosci Rep. 2018;38: pubmed publisher

product information

Catalog No :

GTX27960

Product Name :

p21 Cip1 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

1.00 ml

list of Pubmed id :

24763901

Isotype :

IgG

Product Description :

Rabbit polyclonal antibody to p21 Cip1

CrossReactivity :

Hu, Ms, Rat

Background :

Cell cycle progression is regulated by cyclins and their cognate Cdks (1-3). p21 (WAF1/Cip1) inhibits the activity of each member of the cyclin/Cdk family and over expression of this protein inhibits the proliferation of mammalian cells (5). The expression of p21 is inducible by a wide range of stress stimuli and its transcription can be enhanced by p53 (6). Another member of the CDIs is p27 (also known as Kip1), which also sees up regulation in response to antimitogenic stimuli (7). The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes, like cyclin D1/Cdk4 (4,8). An additional CDI has been found to bind Cdk4 and Cdk6, p16 (INK4A), and when such complexes are formed, the progression of the cell cycle is halted (9). It has become increasingly clear that p16 is a very important tumor suppressor gene whose frequent loss occurs early in many human cancers. p16 is a major target in carcinogenesis that is rivaled in frequency only by p53 (10).

Immunogen :

Synthetic peptide (Human) (C terminal).

Specificity :

Reacts with p21(also designated WAF1/Cip1)

Buffer :

PBS with 0.1% sodium azide

Uses :

IHC-Fr, IP, WB

Concentration :

0.2mg/ml

General References :

Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.