This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
beta Catenin antibody
catalog :
GTX26302
quantity :
100.00μl
price :
289 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunohistochemistry - frozen section
product information
Catalog No :
GTX26302
Product Name :
beta Catenin antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary antibody
Size :
100.00μl
List Price :
289 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal antibody to beta Catenin
CrossReactivity :
Hu, Ms, Pig, Rat, Zfsh, Fsh, Xl
Background :
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues (1,2,3) bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. (6,7) They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. (4,5) Absence of alpha-catenin is found in certain tumor cell lines (8) and reduced levels in certain human carcinomas (9). Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. (10) This interaction involves a 15-aa repeat in the APC. (11) Beta-catenin cell levels seem to be controlled by APC. (12) The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR. (13)
Immunogen :
Synthetic peptide: PGDSNQLAWFDTDL conjugated to KLH, corresponding to amino acids 768-781 of Human or mouse Catenin.
Specificity :
Reacts in dot blot with beta-catenin peptide 768-781 conjugated to BSA.In immunoblots, reacts with a 94kD protein in extracts of Madin-Darby Bovine Kidney (MDBK) cultured cells. Specific staining is inhibited following pre-incubation of the antiserum with the beta-catenin peptide.Shows no reactivity with BSA conjugated alpha catenin peptide (amino acids 890-901).
Buffer :
Preservative: 15mM Sodium Azide; Constituents: Whole Serum
Uses :
Dot, ICC/IF, IHC-Fr, WB
Concentration :
whole antiserum
General References :
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
company information
GeneTex
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