This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
AKT antibody
catalog :
GTX26076
quantity :
1.00 ml
price :
299 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation
product information
Catalog No :
GTX26076
Product Name :
AKT antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary antibody
Size :
1.00 ml
List Price :
299 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal antibody to Akt
CrossReactivity :
Hu, Ms, Rat
Background :
Akt1, also known as Protein kinase B, is a serine/threonine kinase that is at the center of many signal transduction pathways. Akt1 regulates glucose metabolism, transcription, apoptosis, cell proliferation, angiogenesis, and cell motility. The activation of Akt1 occurs downstream of PI-3K, which upon activation by an extracellular molecule, generates PIP. PIP is a lipid second messenger that promotes the translocation of Akt1 to the plasma membrane via PH (pleckstrin-homology) domain binding. At the plasma membrane Akt1 is phosphorylated and activated by PDK-1 at its catalytic site on residue Thr308. Residue Ser473 is also phosphorylated at this time but the kinase has not yet been identified. In this activated form Akt1 phosphorylates proteins that contain the motif, R-x-R-x-x-S/T-F/L, at the plasma membrane, in the cytosol, and in the nucleus. In addition to its kinase activity, Akt1 forms complexes with other proteins that are not substrates. These other proteins act as modulators of Akt1 activity.
Immunogen :
Synthetic peptide mapping to the carboxy terminal domain of human Akt1.
Buffer :
Phosphate-buffered saline containing 0.1% sodium azide and 0.2% gelatin
Uses :
IHC, IP, WB
Concentration :
0.385mg/ml
General References :
Keep as concentrated solution, aliquot and store at 4°C.
company information
GeneTex
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