c-Met (phospho Tyr1365) antibody | GeneTex GTX25672 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

c-Met (phospho Tyr1365) antibody

catalog :

GTX25672

quantity :

50.00μl

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog No :

GTX25672

Product Name :

c-Met (phospho Tyr1365) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

50.00μl

List Price :

289 USD

Isotype :

IgG

Product Description :

Rabbit polyclonal to Met ( c - Met ) ( phospho Y1365 )

CrossReactivity :

Hu, Ms, Rat

Background :

Binding of scatter factor (SF)/hepatocyte growth factor (HGF) to the c Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. c Met contains three tyrosines (Tyrx- x-x-Tyr-Tyr motif) within the activation loop of the catalytic domain. This is also seen with the insulin receptor, insulin-like growth factor receptor (IGF1R) and nerve growth factor (NGF) receptors/Trks, for which phosphorylation of all three tyrosines is required for full activation. With c Met (and the related family member, RON) phosphorylation of Tyr1234 and Tyr1235 have been shown to be important in receptor activation. Activation of the c Met receptor results in binding and/or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, cortactin, paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, ERK1&2, JNK1&2, PLC gamma, and STAT3). The phosphorylation of Tyr1365 has been shown to inhibit cell morphogenesis.

Immunogen :

Synthetic phosphopeptide (Human) derived from the region of c Met that contains tyrosine 1365.

Buffer :

Preservative: 0.05% Sodium Azide; Constituents: PBS, 1mg/ml BSA. pH 7.4

Uses :

Concentration :

0.5mg/ml

General References :

Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.