This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
IRS1 (phospho Tyr896) antibody
catalog :
GTX24873
quantity :
50.00μl
price :
289 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot
product information
Catalog No :
GTX24873
Product Name :
IRS1 (phospho Tyr896) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen Modification :
Phosphorylated
Product Type :
Primary antibody
Size :
50.00μl
List Price :
289 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal to IRS1 ( phospho Y896 )
CrossReactivity :
Hu, Ms, Rat
Background :
Insulin Receptor Substrate 1 (IRS 1) is a 165 kDa multi-phosphorylated cytoplasmic docking protein involved in the regulation of metabolism and proliferation by insulin, IL-4, and other cytokines. Insulin binding to the insulin receptor activates the catalytic domain and causes phosphorylation on tyrosine residues of IRS proteins, which in turn serve to recruit a variety of Src homology 2 (SH2) domain-containing proteins such as PI3 kinase, Grb 2, SHP 2, Nck and Crk. These proteins further propagate intracellular signalling, culminating in both metabolic and growth-promoting functions of IRS 1. pTyr896 of IRS 1 is a Grb 2 SH2 domain binding site.
Immunogen :
Synthetic peptide derived from a region of IRS 1 that contains tyrosine 896. The sequence is conserved in human, mouse, and rat.
Buffer :
Preservative: 0.05% Sodium Azide; Constituents: PBS, 50% glycerol, 1mg/ml BSA (IgG, protease free). pH 7.4
Uses :
WB
Concentration :
0.5mg/ml
General References :
Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
company information
GeneTex
questions and comments