This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
Tau (phospho Ser422) antibody
catalog :
GTX24862
quantity :
50.00μl
price :
289 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot
product information
Catalog No :
GTX24862
Product Name :
Tau (phospho Ser422) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen Modification :
Phosphorylated
Product Type :
Primary antibody
Size :
50.00μl
List Price :
289 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal to Tau ( phospho S422 )
CrossReactivity :
Hu, Ms, Rat
Background :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions seen in Alzheimeris disease (AD). Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK 3 beta, PKA, Cdk 5, MARK, MAPKs, and casein kinase II can phosphorylate tau. Serine 422 can be phosphorylated by members of the MAP kinase (MAPK) family.
Immunogen :
Synthetic peptide (Human) derived from a region of human tau that contains serine 422. The region surrounding serine 422 is also conserved in mouse and rat.
Specificity :
Phosphorylation site-specific antibody selective for the phosphorylated form of human tau containing a phosphate on serine 422.
Buffer :
Preservative: 0.05% Sodium Azide; Constituents: PBS,50% glycerol, 1mg/ml BSA. pH 7.3
Uses :
WB
Concentration :
0.25mg/ml
General References :
Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
company information
GeneTex
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