eIF2 alpha (phospho Ser52) antibody | GeneTex GTX24837 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

eIF2 alpha (phospho Ser52) antibody

catalog :

GTX24837

quantity :

50.00μl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

product information

Catalog No :

GTX24837

Product Name :

eIF2 alpha (phospho Ser52) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

50.00μl

list of Pubmed id :

18694499

Isotype :

IgG

Product Description :

Rabbit polyclonal antibody to eIF2 alpha (phospho Ser52)

CrossReactivity :

Hu, Ms

Background :

eIF-2 alpha is a 36 kDa protein which is ubiquitously expressed in many cell types. The eIF-2 protein, which is composed of three subunits (alpha, beta and gamma), is one of the key molecules in the initiation of translation. In mammalian cells, eIF-2 alpha is phosphorylated at serine 52 by at least two kinases: the haem-controlled repressor (HCR) and the interferon inducible double stranded RNA-dependent protein kinase (PKR). Phosphorylation of eIF-2 alpha blocks the GDP-GTP exchange activity of eIF-2 beta, resulting in the suppression of protein synthesis. The phosphorylation of eIF-2 alpha is an important regulatory process in protein synthesis.

Immunogen :

Synthetic peptide (Human) derived from the region of human eIF-2 alpha that contains serine 52. This region is conserved among many species including rat, pig, cow, fruit fly, and yeast.

Buffer :

Preservative: 0.05% Sodium Azide; Constituents: 50% Glycerol, PBS, 1mg/ml BSA (IgG, protease free). pH 7.3

Uses :

ICC/IF, WB

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.