FAK (phospho Ser722) antibody | GeneTex GTX24790 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

FAK (phospho Ser722) antibody

catalog :

GTX24790

quantity :

50.00μl

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog No :

GTX24790

Product Name :

FAK (phospho Ser722) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

50.00μl

List Price :

289 USD

Isotype :

IgG

Product Description :

Rabbit polyclonal to FAK ( phospho S722 )

CrossReactivity :

Hu, Ms, Rat, Xl

Background :

Focal Adhesion Kinase is a non-receptor protein tyrosine kinase discovered as a substrate for Src and it is a key protein in integrin, growth factor and bioactive peptide signaling. Focal Adhesion Kinase plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. Focal Adhesion Kinase regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion; however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis. The role of phosphorylation at Ser722 is currently being actively investigated.

Immunogen :

Synthetic peptide phosphopeptide derived from the region of FAK that contains serine 722.

Specificity :

Phosphorylation site-specific antibody (PSSA) selective for the phosphorylated form of the Focal Adhesion Kinase enzyme containing a phosphate on serine 722. The antibody has been shown to recognize FAK (approximately 125 kDa) in human epithelial carcinoma cells.

Buffer :

Preservative: 0.05% Sodium Azide; Constituents: PBS, 1.0mg/ml BSA (IgG, protease free). pH 7.4

Uses :

Concentration :

batch dependent

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.