Raf1 (phospho Ser338/Tyr340) antibody | GeneTex GTX24768 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

Raf1 (phospho Ser338/Tyr340) antibody

catalog :

GTX24768

quantity :

50.00μl

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog No :

GTX24768

Product Name :

Raf1 (phospho Ser338/Tyr340) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

50.00μl

List Price :

289 USD

Isotype :

IgG

Product Description :

Rabbit polyclonal antibody to Raf1 (phospho Ser338/Tyr340)

CrossReactivity :

Hu, Ms, Rat

Background :

The Raf family of serine/threonine-specific kinases is comprised of three members (A-Raf, B-Raf, and c-Raf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen-activated protein kinase (MAPK) pathway. c-Raf kinase (also known as Raf-1) is a key 74 kDa signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Phosphorylation of serine 338 creates a recognition site for tyrosine kinases and is critical for the activation of c-Raf. Serine 338 to tyrosine 341 (SSYY) is the phosphoregulatory site which regulates the biological function of the c-Raf tyrosine kinase by oncogenic Ras and Src.

Immunogen :

Synthetic peptide (Human) derived from a region of human c-Raf that contains serine 338 and tyrosine 340. The sequence is conserved in mouse and rat.

Specificity :

A-Raf (57%) has not been tested, but is not expected to react.

Buffer :

Preservative: 0.05% Sodium Azide; Constituents: PBS, 1.0mg/ml BSA (IgG, protease free). pH 7.3

Uses :

General References :

Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.