alpha Synuclein antibody [4B12] | GeneTex GTX21904 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

alpha Synuclein antibody [4B12]

catalog :

GTX21904

quantity :

100.00μl

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B12

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Catalog No :

GTX21904

Product Name :

alpha Synuclein antibody [4B12]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

299 USD

Clone :

4B12

Isotype :

IgG1

Product Description :

Mouse monoclonal [4B12] to alpha Synuclein

CrossReactivity :

Background :

The implication of alpha synuclein in neurodegenerative diseases started after the identification of non A beta component of amyloid (NAC peptide) in Alzheimeris disease (AD) brains.There is now a general group of synucleinopathies which implicates alpha synuclein in Lewy body syndromes, Parkinsonis disease, and Alzheimeris disease. Certain missense mutations in the alpha synuclein gene (A53T, A30P) have been linked to the familial Parkinsonis disease (PD). Alpha synuclein is the major component of Lewy bodies and Lewy neuritis in sporadic PD, dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kD) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma synuclein and synoretin.The expression is abundant in neurons and typically localized at presynaptic terminals. Antibodies to alpha synuclein provide a specific method to detect Lewy bodies and associated pathological mechanism of PD and AD.

Immunogen :

Recombinant human alpha synuclein produced in E. coli.

Buffer :

Preservative: 0.1% Sodium Azide; Constituents: PBS

Uses :

Dot, ELISA, IHC, IHC-Fr, IHC-P, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.