5-Methylcytosine / 5-mC antibody | GeneTex GTX21884 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

5-Methylcytosine / 5-mC antibody

catalog :

GTX21884

quantity :

250.00μg

price :

299 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS, immunohistochemistry - frozen section

product information

Catalog No :

GTX21884

Product Name :

5-Methylcytosine / 5-mC antibody

Host Species :

Sheep

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

250.00μg

List Price :

299 USD

list of Pubmed id :

21223309,19201949,21630420,22379135,19660178

Isotype :

IgG

Product Description :

Sheep polyclonal to 5-Methylcytosine / 5-mC

CrossReactivity :

Ms, Rat, Zfsh

Background :

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.

Immunogen :

Chemical - Small Molecule conjugated to KLH.

Specificity :

This antibody is specific for 5-Methyl Cytosine. It was tested using immunoprecipitation against 5-Methyl Cytosine and bromodeoxyuridine (BrdU) or - control (no antigen).

Buffer :

0.15M PBS, pH7.5

Uses :

Dot, FACS, ICC/IF, IHC, IHC-Fr, IP, WB

Concentration :

1.9mg/ml

General References :

Aliquot and store at -20°:C long term. Avoid repeated freeze-thaw cycles