FGFR1 antibody [M2F12] | GeneTex GTX20829 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

FGFR1 antibody [M2F12]

catalog :

GTX20829

quantity :

125.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M2F12

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 3

Reference
Canalejo R, Canalejo A, Martinez-Moreno J, Rodriguez-Ortiz M, Estepa J, Mendoza F, et al. FGF23 fails to inhibit uremic parathyroid glands. J Am Soc Nephrol. 2010;21:1125-35 pubmed publisher
Rodriguez-Ortiz M, Canalejo A, Herencia C, Martinez-Moreno J, Peralta-Ramírez A, Perez-Martinez P, et al. Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration. Nephrol Dial Transplant. 2014;29:282-9 pubmed publisher
Lopez I, Rodriguez-Ortiz M, Almaden Y, Guerrero F, de Oca A, Pineda C, et al. Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo. Kidney Int. 2011;80:475-82 pubmed publisher

product information

Catalog No :

GTX20829

Product Name :

FGFR1 antibody [M2F12]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

125.00μg

List Price :

299 USD

list of Pubmed id :

21525854,20431039,24103811

Clone :

M2F12

Isotype :

IgG2a

Product Description :

Mouse monoclonal antibody [M2F12] to FGFR1

CrossReactivity :

Hu, Ms, Rat

Background :

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq]

Immunogen :

Recombinant human ectodomain of FGFr1a expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.

Specificity :

Reacts with alpha isoform of FRFR1.

Buffer :

Phosphate-buffered saline, pH 7.4, containing no preservatives

Uses :

IHC-Fr, IHC-P, IP, WB

Concentration :

1.1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.