c-Myc antibody [9E11] | GeneTex GTX20056 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

c-Myc antibody [9E11]

catalog :

GTX20056

quantity :

100.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9E11

reactivity :

human, mouse

application :

western blot, ELISA, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 4

Reference
Wilmes G, Archambault V, Austin R, Jacobson M, Bell S, Cross F. Interaction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch. Genes Dev. 2004;18:981-91 pubmed
Sbia M, Parnell E, Yu Y, Olsen A, Kretschmann K, Voth W, et al. Regulation of the yeast Ace2 transcription factor during the cell cycle. J Biol Chem. 2008;283:11135-45 pubmed publisher
Bean J, Siggia E, Cross F. High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae. Genetics. 2005;171:49-61 pubmed
Roberts D, Wilson B, Huff J, Stewart A, Cairns B. Dephosphorylation and genome-wide association of Maf1 with Pol III-transcribed genes during repression. Mol Cell. 2006;22:633-44 pubmed

product information

Catalog No :

GTX20056

Product Name :

c-Myc antibody [9E11]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

299 USD

list of Pubmed id :

15105375,15965243,16762836,18292088

Clone :

9E11

Isotype :

IgG2a

Product Description :

Mouse monoclonal [9E11] to c-Myc

CrossReactivity :

Hu, Ms

Background :

The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

Immunogen :

Synthetic peptide: AEEQKLISEEDL conjugated to KLH, corresponding to amino acids 408-420 of Human c-Myc.

Buffer :

Phosphate-buffered saline

Uses :

ELISA, IHC-Fr, IHC-P, IP, WB, ChIP assay

Concentration :

0.7mg/ml

General References :

Keep as concentrated solution. Store at 4¼C short term. For extended storage aliquot and store at -20¼C or below. Avoid freeze-thaw cycles.