CD19 antibody [SJ25-C1] (Biotin) | GeneTex GTX19665 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

CD19 antibody [SJ25-C1] (Biotin)

catalog :

GTX19665

quantity :

100.00μg

price :

289 USD

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

SJ25-C1

reactivity :

human

product information

Catalog No :

GTX19665

Product Name :

CD19 antibody [SJ25-C1] (Biotin)

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Biotin

Product Type :

Primary antibody

Size :

100.00μg

List Price :

289 USD

Clone :

SJ25-C1

Isotype :

IgG1

Product Description :

Mouse monoclonal [SJ25-C1] to CD19 (Biotin)

CrossReactivity :

Background :

CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It is expressed on approximately 10% of normal human peripheral blood cells and approximately 60% of splenic lymphocytes. It is not expressed on granulocytes, monocytes or T cells as defined by CD3 expression. CD19 defines a pan B antigen which is expressed from the earliest stages of B progenitor development, but is lost on terminal differentiation to plasma cells. It may also be present on some early myeloid progenitors, particularly those of the monoblastic type. The CD19 antigen is expressed on approximately 12% of peripheral blood lymphocytes. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias. Recent cDNA cloning of CD19 has shown significant homology in the cytoplasmic domain of CD19 with the int1 oncogene.

Immunogen :

NALM-1 human cell line.

Specificity :

GTX13458 recognizes the human CD19 (90 kDa) integral membrane glycoprotein and may be used for:1. Identification of pan B cells and B progenitors.2. Identification of germinal center B cells.

Buffer :

Preservative: 0.09% Sodium Azide. Constituents: 1.0% BSA, 0.01M PBS. pH 7.2

Uses :

FACS

Concentration :

0.2mg/ml

General References :

Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.