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product summary
company name :
GeneTex
product type :
antibody
product name :
Vimentin antibody [SP20]
catalog :
GTX16700
quantity :
500.00μl
price :
299 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
SP20
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, FACS, immunohistochemistry - paraffin section
citations: 1
product information
Catalog No :
GTX16700
Product Name :
Vimentin antibody [SP20]
Host Species :
Rabbit
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
500.00μl
List Price :
299 USD
list of Pubmed id :
22574222
Clone :
SP20
Isotype :
IgG
Product Description :
Rabbit monoclonal [SP20] to Vimentin
CrossReactivity :
Hu
Background :
Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of malignant tumors, generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
Immunogen :
Recombinant full length protein (Human).
Buffer :
Preservative: 0.1% Sodium Azide. Constituents: Tissue culture supernatant
Uses :
FACS, ICC/IF, IHC, IHC-P, WB
General References :
Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
Image Legend_4 :
Human tosil stained with anti-vimentin antibody
Image Legend_5 :
Human Colon Adencarcinoma stained with anti-Vimentin antibody
Image Legend_6 :
Human Prostate Adenocarcinoma stained with anti-Vimentin antibody
Image Legend_7 :
Human Hepatocellular Carcinoma stained with anti-Vimentin antibody
Image Legend_8 :
Human Lung Squamous Cell Carcinoma stained with anti-Vimentin antibody
Image Legend_9 :
Human Renal Cell Carcinoma stained with anti-Vimentin antibody
Image Legend_10 :
Human Breast Ductal Cell Carcinoma stained with anti-Vimentin antibody
Image Legend_11 :
Human Bladder Transitional Cell Carcinoma stained with anti-Vimentin antibody
Image Legend_12 :
Human Ovary Adenocarcinoma stained with anti-Vimentin antibody
Image Legend_13 :
Human Stomach Adenocarcinoma stained with anti-Vimentin antibody
company information
GeneTex
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