This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
Cyclin D1 antibody [SP4]
catalog :
GTX16663
quantity :
500.00μl
price :
399 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
SP4
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
citations: 1
| Reference |
|---|
Wijnhoven S, Speksnijder E, Liu X, Zwart E, vanOostrom C, Beems R, et al. Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res. 2007;67:4648-56 pubmed
|
product information
Catalog No :
GTX16663
Product Name :
Cyclin D1 antibody [SP4]
Host Species :
Rabbit
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
500.00μl
List Price :
399 USD
list of Pubmed id :
17510390
Clone :
SP4
Product Description :
Rabbit monoclonal [SP4] to Cyclin D1
CrossReactivity :
Hu, Ms, Rat
Background :
During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer.
Immunogen :
Synthetic peptide (Human) (C terminal).
Buffer :
Preservative: 0.1% Sodium Azide
Uses :
IHC, IHC-P, WB
Concentration :
tissue culture supernatant
General References :
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Image Legend_4 :
Human Endometrial Adenocarcinoma stained with anti-Cyclin D1 antibody
Image Legend_5 :
Human Mantle Cell Lymphoma stained with anti-Cyclin D1 antibody
Image Legend_6 :
Human B Cell Lymphoma stained with anti-Cyclin D1 antibody
Image Legend_7 :
Human HK Lymphoma stained with anti-Cyclin D1 antibody
Image Legend_8 :
Human Lung Adenocarcinoma stained with anti-Cyclin D1 antibody
Image Legend_9 :
Human Ovarian Adenocarcinoma stained with anti-Cyclin D1 antibody
Image Legend_10 :
Human Pancreatic Adenocarcinoma stained with anti-Cyclin D1 antibody
Image Legend_11 :
Human Prostate Adenocarcinoma stained with anti-Cyclin D1 antibody
Image Legend_12 :
Human Renal Cell Carcinoma stained with anti-Cyclin D1 antibody
company information
GeneTex
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