Tyrosine Hydroxylase (phospho Ser40) antibody | GeneTex GTX16557 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

Tyrosine Hydroxylase (phospho Ser40) antibody

catalog :

GTX16557

quantity :

100.00μl

price :

399 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 5

Reference
Matragrano L, Sanford S, Salvante K, Sockman K, Maney D. Estradiol-dependent catecholaminergic innervation of auditory areas in a seasonally breeding songbird. Eur J Neurosci. 2011;34:416-25 pubmed publisher
Matragrano L, Beaulieu M, Phillip J, Rae A, Sanford S, Sockman K, et al. Rapid effects of hearing song on catecholaminergic activity in the songbird auditory pathway. PLoS ONE. 2012;7:e39388 pubmed publisher
Gammie S, Edelmann M, Mandel-Brehm C, D'Anna K, Auger A, Stevenson S. Altered dopamine signaling in naturally occurring maternal neglect. PLoS ONE. 2008;3:e1974 pubmed publisher
Ellis J, Riters L. Patterns of phosphorylated tyrosine hydroxylase vary with song production in female starlings. Brain Res. 2013;1498:41-9 pubmed publisher
Heimovics S, Prior N, Maddison C, Soma K. Rapid and widespread effects of 17β-estradiol on intracellular signaling in the male songbird brain: a seasonal comparison. Endocrinology. 2012;153:1364-76 pubmed publisher

product information

Catalog No :

GTX16557

Product Name :

Tyrosine Hydroxylase (phospho Ser40) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μl

List Price :

399 USD

list of Pubmed id :

18398484,22294743,22724011,21714815,23270608

Product Description :

Rabbit polyclonal to Tyrosine Hydroxylase ( phospho S40 ) - Neuronal Marker

CrossReactivity :

Hu, Ms, Mk, Pig, Rat, Bird, Ql

Background :

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long term changes in activity of the enzyme and its availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are a consistent neurochemical abnormality.

Immunogen :

Was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Ser40 of rat Tyrosine Hydroxylase (TH).

Buffer :

Preservative: 0.1% Sodium Azide; Constituents: 10% Glycerol, 0.05% Tween 20, PBS (divalent cation deficient), 1mg/ml BSA, 20mM Tris HCl pH7.6, 10mM HEPES pH7.2, 0.1% PVP-40.

Uses :

ICC/IF, IHC, IHC-Fr, WB

Concentration :

0.1mg/ml

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.