This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
Fas antibody [H11]
catalog :
GTX16104
quantity :
50.00μg
price :
299 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
H11
reactivity :
human, mouse, dog
application :
western blot, immunocytochemistry, FACS
product information
Catalog No :
GTX16104
Product Name :
Fas antibody [H11]
Host Species :
Rat
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
50.00μg
List Price :
299 USD
Clone :
H11
Isotype :
IgG2a
Product Description :
Rat Monoclonal antibody [H11] to Fas
CrossReactivity :
Hu, Ms, Dog, Cat
Background :
Fas / APO1 (CD95) is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas Ligand system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumours. Tumour cells frequently exhibit de novo expression of Fas Ligand, which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas Ligand system. Fas is believed to be involved in various autoimmune diseases including ulcerative colitis, Graves disease, and rheumatoid arthritis. Fas expression on gastric epithelial cells in patients infected with H. Pylori is responsible for the accelerated apoptosis of the cells. Serum Fas Ligand concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension.
Immunogen :
Synthetic peptide: RGQSCNNQPLNHKVYMRNSKYPEDL, corresponding to amino acids 196-220 of Mouse Fas Ligand.
Buffer :
Preservative: 0.02% Sodium Azide; Constituents: PBS
Uses :
FACS, ICC/IF, WB
Concentration :
1mg/ml
General References :
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
company information
GeneTex
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