Fas antibody [H11] (Biotin) | GeneTex GTX16103 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Fas antibody [H11] (Biotin)

catalog :

GTX16103

quantity :

50.00 test

price :

299 USD

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

H11

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, FACS

product information

Catalog No :

GTX16103

Product Name :

Fas antibody [H11] (Biotin)

Host Species :

Rat

Clonality :

Monoclonal

Conjugation :

Biotin

Product Type :

Primary antibody

Size :

50.00 test

List Price :

299 USD

Clone :

H11

Isotype :

IgG2a

Product Description :

Rat Monoclonal antibody [H11] to Fas

CrossReactivity :

Hu, Ms, Rat

Background :

Fas / APO1 (CD95) is an important member of the tumour necrosis factor (TNF) superfamily involved in membrane-mediated apoptosis. Ligation of Fas by Fas Ligand or an anti-Fas cross-linking antibody, triggers activation of the caspase cascade. Functional impairment of the Fas / Fas Ligand system is associated with the development and progression of malignancies. Fas gene mutations have been suggested to have a role in testicular germ cell tumours. Tumour cells frequently exhibit de novo expression of Fas Ligand, which plays a significant role in local tissue destruction, metastatic spread, and immune escape of the tumor cells. The apoptosis of lymphocytes, which occurs in autoimmune diseases, is usually induced by the Fas/Fas Ligand system. Fas is believed to be involved in various autoimmune diseases including ulcerative colitis, Graves disease, and rheumatoid arthritis. Fas expression on gastric epithelial cells in patients infected with H. Pylori is responsible for the accelerated apoptosis of the cells. Serum Fas Ligand concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension.

Immunogen :

Synthetic peptide: RGQSCNNQPLNHKVYMRNSKYPEDL, corresponding to amino acids 196-220 of Mouse Fas Ligand.

Buffer :

Preservative: 0.02% Sodium Azide; Constituents: PBS

Uses :

FACS, ICC/IF, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.