alpha Synuclein antibody | GeneTex GTX15530 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

alpha Synuclein antibody

catalog :

GTX15530

quantity :

500.00μl

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog No :

GTX15530

Product Name :

alpha Synuclein antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

500.00μl

List Price :

289 USD

Isotype :

IgG

Product Description :

Rabbit polyclonal to alpha Synuclein

CrossReactivity :

Hu, Rat

Background :

The implication of alpha synuclein in neurodegenerative diseases started after the identification of non A beta component of amyloid (NAC peptide) in Alzheimer's disease (AD) brains. There is now a general group of synucleinopathies which implicates alpha synuclein in Lewy body syndromes, Parkinson' disease, and Alzheimer's disease. Certain missense mutations in the alpha synuclein gene (A53T, A30P) have been linked to the familial Parkinson's disease (PD). Alpha Synuclein is the major component of Lewy bodies and Lewy neuritis in sporadic PD, dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kD) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma synuclein and synoretin. The expression is abundant in neurons and typically is localized at presynaptic terminals. Antibodies to alpha synuclein provide a specific method to detect Lewy bodies and associated pathological mechanism of PD and AD.

Immunogen :

The immunogen is located within aa 110-138 of Uniprot:P37840.

Specificity :

Specific for alpha synuclein.Does not cross react with beta synuclein.

Buffer :

Phosphate-buffered saline, pH 7.4 containing 1% BSA and 0.09% sodium azide

Uses :

IHC, IHC-P

Concentration :

0.2mg/ml

General References :

Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.