Carbonic Anhydrase IX antibody | GeneTex GTX15086 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

Carbonic Anhydrase IX antibody

catalog :

GTX15086

quantity :

100.00μl

price :

299 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Catalog No :

GTX15086

Product Name :

Carbonic Anhydrase IX antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

299 USD

Isotype :

IgG

Product Description :

Rabbit polyclonal to Carbonic Anhydrase IX

CrossReactivity :

Hu, Ms, Dog, Rat

Background :

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. Because of its functionality, it has become an important diagnostic marker for various cancers, most notably renal cell carcinoma (RCC). There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Immunogen :

Synthetic peptide (C terminal).

Buffer :

Preservative: 0.1% Sodium Azide

Uses :

ICC/IF, IHC, IHC-Fr, IHC-P, WB

Concentration :

1.1mg/ml

General References :

Store at 4ºC

Image Legend_4 :

Immunohistochemistry-Frozen: Carbonic Anhydrase IX Antibody (GTX15086) - Analysis of human colon carcinoma, xenografted in mice.

Image Legend_5 :

Western Blot: Carbonic Anhydrase IX Antibody (GTX15086) - Analysis of Carbonic Anhydrase IX expression in 1) HeLa, 2) MDA-MB-231 and 3) A549 whole cell lysates.

Image Legend_6 :

Western Blot: Carbonic Anhydrase IX Antibody (GTX15086) - Detection of carbonic anhydrase IX in transfected HEK cell lysate using GTX15086. Rabbit IgG was used as a negative control.

Image Legend_7 :

Western Blot: Carbonic Anhydrase IX Antibody (GTX15086) - Analysis of CAIX on rat renal cortex using GTX15086.