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product summary
company name :
GeneTex
product type :
antibody
product name :
BTK (phospho Ser180) antibody [3i5]
catalog :
GTX14393
quantity :
50.00μl
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
3i5
reactivity :
human
application :
western blot, immunoprecipitation
product information
Catalog No :
GTX14393
Product Name :
BTK (phospho Ser180) antibody [3i5]
Host Species :
Mouse
Clonality :
Monoclonal
Antigen Modification :
Phosphorylated
Product Type :
Primary antibody
Size :
50.00μl
List Price :
299 USD
Clone :
3i5
Isotype :
IgG3
Product Description :
Mouse monoclonal [3i5] to BTK ( phospho S180 )
CrossReactivity :
Hu
Background :
Brutons tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-located Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of Btk is negatively regulated by PKCbeta through phosphorylation of Btk at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/Btk inhibitory signal is likely to be a key determinant of the B-cell receptor signaling threshold to maintain optimal Btk activity.
Immunogen :
Synthetic peptide conjugated to KLH.
Buffer :
Preservative: NoneConstituents: 50% Glycerol, 0.1mg/ml BSA, 150mM Sodium Chloride, 10mM HEPES. pH 7.5
Uses :
IP, WB
Concentration :
0.1mg/ml
General References :
Keep as concentrated solution. Store at -20°C.
company information
GeneTex
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