This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
Caspase 1 antibody [14F468]
catalog :
GTX14367
quantity :
50.00μg
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
14F468
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
product information
Catalog No :
GTX14367
Product Name :
Caspase 1 antibody [14F468]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
50.00μg
List Price :
299 USD
Clone :
14F468
Isotype :
IgG1
Product Description :
Mouse monoclonal [14F468] to Caspase 1
CrossReactivity :
Hu, Pig, Rat
Background :
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role in down stream of Caspase 8 which is involved in Fas-mediated apoptosis.
Immunogen :
Synthetic peptide: RKVRFSFEQPDGRAQMPTTE , corresponding to amino acids 371-390 of Human Caspase 1.
Buffer :
Preservative: 0.05% Sodium Azide; Constituents: 0.2% Gelatin, PBS
Uses :
IHC, IHC-P, WB
Concentration :
0.5mg/ml
General References :
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Image Legend_4 :
Western blot analysis of Caspase-1 using a Caspase-1 monoclonal antibody. Human HeLa (A) and mouse NIH3T3 lysate probed with Caspase-1 antibody at 0.5 ug/ml and 2 ug/ml, respectively.
company information
GeneTex
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