product summary
company name :
GeneTex
product type :
antibody
product name :
Aurora A antibody [35C1]
catalog :
GTX13824
quantity :
50.00μg
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
35C1

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
GeneTex product webpage
citations: 7
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; fig 1
  • western blot; human; fig 2
Wen Q, Yang Q, Goldenson B, Malinge S, Lasho T, Schneider R, et al. Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition. Nat Med. 2015;21:1473-80 pubmed publisher
  • western blot; human; fig 1
Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Pakala S, Nair V, Reddy S, Kumar R. Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization. J Biol Chem. 2012;287:40560-9 pubmed publisher
Goldenson B, Kirsammer G, Stankiewicz M, Wen Q, Crispino J. Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation. Blood. 2015;125:2141-50 pubmed publisher
Chang K, Chang W, Chang Y, Hung L, Lai C, Yeh Y, et al. Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma. PLoS ONE. 2013;8:e79863 pubmed publisher
Yang G, Mercado-Uribe I, Multani A, Sen S, Shih I, Wong K, et al. RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013;133:275-85 pubmed publisher
Chen Y, Lin H, Chen J, Tsai M, Hsieh H, Chang J, et al. CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. Int J Cancer. 2014;135:751-62 pubmed publisher
image
image 1 :
GeneTex GTX13824 image 1
Recombinant Aurora kinase detected with Mouse anti-Aurora-A kinase (GTX13824)
product information
Catalog No :
GTX13824
Product Name :
Aurora A antibody [35C1]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
50.00μg
List Price :
299 USD
list of Pubmed id :
24382688,20423983,23055517,23319376,25670627
Clone :
35C1
Isotype :
IgG2b
Product Description :
Mouse monoclonal antibody [35C1] to Aurora A
CrossReactivity :
Hu, Ms
Background :
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen :
Recombinant Aurora A
Specificity :
This antibody recognizes an epitope within the non-catalytic N-terminal domain of Aurora A. Clone 35C1 does not inhibit Aurora A kinase activity (Cremet et al. 2003).
Buffer :
Phosphate buffered saline containing 0.09% Sodium Azide
Uses :
ICC/IF, IHC, IP, WB
General References :
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
more info or order :
GeneTex product webpage
company information
GeneTex
2456 Alton Pkwy
Irvine, CA92606
info@genetex.com
www.genetex.com
1-877-436-3839
headquarters: USA