4E-BP1 (phospho Thr37/Thr46) antibody | GeneTex GTX133181 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

4E-BP1 (phospho Thr37/Thr46) antibody

catalog :

GTX133181

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

GTX133181

Product Name :

4E-BP1 (phospho Thr37/Thr46) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary Antibody

Background :

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq]