AKT (phospho Ser473/474/472) antibody | GeneTex GTX128414 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

AKT (phospho Ser473/474/472) antibody

catalog :

GTX128414

quantity :

100.00μl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 3c	Liu J, Cao L, Zhao N, Feng Y, Yu Z, Li Y, et al. miR‑338‑3p inhibits A549 lung cancer cell proliferation and invasion by targeting AKT and β‑catenin signaling pathways. Mol Med Rep. 2019;20:33-40 pubmed publisher
	Huang L, Tam K, Liu W, Lin C, Hsu K, Hsieh W, et al. CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Dis Markers. 2018;2018:3835783 pubmed publisher
	Vallejo Flores G, Torres J, Sandoval Montes C, ArÃ©valo Romero H, Meza I, Camorlinga Ponce M, et al. Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. Biomed Res Int. 2015;2015:761501 pubmed publisher

product information

Catalog No :

GTX128414

Product Name :

AKT (phospho Ser473/474/472) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μl

Product Description :

Rabbit Polyclonal antibody to AKT1+2+3 (phospho Ser473/474/472) (v-akt murine thymoma viral oncogene homolog 1)

CrossReactivity :

Background :

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]

Buffer :

1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Uses :

IP, WB

Concentration :

0.96mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.