Histone H2A.XS139ph (phospho Ser139) antibody | GeneTex GTX127342 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Histone H2A.XS139ph (phospho Ser139) antibody

catalog :

GTX127342

quantity :

200.00μl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

zebrafish

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; zebrafish ; fig 3	Chun C, Wu Y, Lee S, Williamson E, Reinert B, Jaiswal A, et al. The homologous recombination component EEPD1 is required for genome stability in response to developmental stress of vertebrate embryogenesis. Cell Cycle. 2016;15:957-62 pubmed publisher
	Singh A, Oehler J, Torrecilla I, Kilgas S, Li S, Vaz B, et al. The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8. EMBO J. 2019;38:e102361 pubmed publisher
	Zada D, Bronshtein I, Lerer Goldshtein T, Garini Y, Appelbaum L. Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Nat Commun. 2019;10:895 pubmed publisher
	González Rosa J, Sharpe M, Field D, Soonpaa M, Field L, BURNS C, et al. Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish. Dev Cell. 2018;44:433-446.e7 pubmed publisher

product information

Catalog No :

GTX127342

Product Name :

Histone H2A.XS139ph (phospho Ser139) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

200.00μl

Isotype :

IgG

Product Description :

Rabbit Polyclonal antibody to zebrafish histone H2A.X (phospho Ser139) (H2A histone family, member X)

CrossReactivity :

Zfsh

Background :

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Buffer :

1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

Uses :

IHC, IHC-P, WB, IHC-Wm

Concentration :

0.6mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.