This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
TET1 antibody [N3C1]
catalog :
GTX124207
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, brewer's yeast
application :
western blot
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 4b
Cheng Y, Sun M, Chen L, Li Y, Lin L, Yao B, et al. Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice. Cell Rep. 2018;25:3194-3203.e4 pubmed publisher
  • western blot; mouse; loading ...; fig 3g
Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, et al. Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency. Nucleic Acids Res. 2018;46:6026-6040 pubmed publisher
  • western blot; brewer's yeast; 1:10,000; fig 1
Weber A, Krawczyk C, Robertson A, Kuśnierczyk A, Vågbø C, Schuermann D, et al. Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun. 2016;7:10806 pubmed publisher
Huang Z, Yu J, Cui W, Johnson B, Kim K, Pfeifer G. The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins. Sci Adv. 2021;7: pubmed publisher
Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I, et al. GADD45A binds R-loops and recruits TET1 to CpG island promoters. Nat Genet. 2019;51:217-223 pubmed publisher
Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stalberg P, Westin G. Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors. BMC Cancer. 2018;18:764 pubmed publisher
Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, et al. Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency. Cell Stem Cell. 2018;23:266-275.e6 pubmed publisher
Zhou Y, Zheng X, Lu J, Chen W, Li X, Zhao L. Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells. Cell Physiol Biochem. 2018;45:2548-2559 pubmed publisher
Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, et al. p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2017;31:959-972 pubmed publisher
Good C, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, et al. A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Nucleic Acids Res. 2017;45:8269-8281 pubmed publisher
Cleven A, Suijker J, Agrogiannis G, Briaire de Bruijn I, Frizzell N, Hoekstra A, et al. IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. Clin Sarcoma Res. 2017;7:8 pubmed publisher
Chen H, Cai W, Chu E, Tang J, Wong C, Wong S, et al. Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice. Oncogene. 2017;36:4415-4426 pubmed publisher
Chen Y, Xu M, Zhang J, Ma J, Gao M, Zhang Z, et al. Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment. Adv Mater. 2017;29: pubmed publisher
Tian Y, Pan F, Sun X, Gan M, Lin A, Zhang D, et al. Association of TET1 expression with colorectal cancer progression. Scand J Gastroenterol. 2017;52:312-320 pubmed publisher
Zhang W, Han D, Wan P, Pan P, Cao Y, Liu Y, et al. ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation. Sci Rep. 2016;6:34543 pubmed publisher
Zhou F, Resendiz M, Lo C, Chen Y. Cell-Wide DNA De-Methylation and Re-Methylation of Purkinje Neurons in the Developing Cerebellum. PLoS ONE. 2016;11:e0162063 pubmed publisher
Yang Y, Zhao J, Fong K, Kim J, Li S, Song C, et al. FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function. Nucleic Acids Res. 2016;44:8153-64 pubmed publisher
Ni K, Dansranjavin T, Rogenhofer N, Oeztuerk N, Deuker J, Bergmann M, et al. TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility. Hum Reprod. 2016;31:1411-24 pubmed publisher
product information
Catalog Number :
GTX124207
Product Name :
TET1 antibody [N3C1]
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary Antibody
list of Pubmed id :
22999938,24002655,24875481,26932196,27141042,27257062,27583369,27708396,27846738,27918113,26136340,26063725,28346420,28484589,28607180,24939750,26186463,29558748,22948384
Background :
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
company information
GeneTex
2456 Alton Pkwy
Irvine, CA92606
info@genetex.com
http://www.genetex.com
1-877-436-3839
headquarters: USA