This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
AKT antibody [N3C2], Internal
catalog :
GTX121937
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry - frozen section
citations: 23
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:150
  • western blot; mouse; 1:1500; loading ...; fig 4b,4c
Wang X, Chen H, Tian R, Zhang Y, Drutskaya M, Wang C, et al. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nat Commun. 2017;8:14091 pubmed publisher
  • western blot; human; loading ...; fig 6
Tomei P, Masola V, Granata S, Bellin G, Carratu P, Ficial M, et al. Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation. J Nephrol. 2016;29:881-891 pubmed
Lee C, Hung P, Liu K, Chung H, Yang W, Hsu K, et al. LDOC1 Suppresses Microbe-Induced Production of IL-1β in Human Normal and Cancerous Oral Cells through the PI3K/Akt/GSK-3β Axis. Cancers (Basel). 2020;12: pubmed publisher
Chen S, Kuo T, Liao Y, Lin M, Tien Y, Huang M. Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. Oncogene. 2018;37:6041-6053 pubmed publisher
Wu P, You Y, Liu Y, Hou C, Wu C, Wen K, et al. Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells. Int J Mol Sci. 2018;19: pubmed publisher
Chang H, Lu C, Chiang J, Tsai F, Juan Y, Tsao J, et al. Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling. Int J Oncol. 2018;: pubmed publisher
Chen P, Lee W, Ling H, Cheng C, Chen K, Lin C. Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells. J Cell Physiol. 2018;233:4972-4980 pubmed publisher
Viedma Rodríguez R, Martínez Hernández M, Flores López L, Baiza Gutman L. Epsilon-aminocaproic acid prevents high glucose and insulin induced-invasiveness in MDA-MB-231 breast cancer cells, modulating the plasminogen activator system. Mol Cell Biochem. 2018;437:65-80 pubmed publisher
Yeh C, Chen C, Leu Y, Lin M, Chiu M, Wang S. The effects of artocarpin on wound healing: in vitro and in vivo studies. Sci Rep. 2017;7:15599 pubmed publisher
Ni Y, Hsieh C, Kim S, Wang J, Su C, Yao C, et al. A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres. Apoptosis. 2017;22:1235-1245 pubmed publisher
Liu J, Cao L, Feng Y, Li Y, Li T. MiR-338-3p inhibits TNF-α-induced lipogenesis in human sebocytes. Biotechnol Lett. 2017;39:1343-1349 pubmed publisher
Chen X, Zhao X, Cai H, Sun H, Hu Y, Huang X, et al. The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. Redox Biol. 2017;12:987-1003 pubmed publisher
Wang H, Wang Y, Wu D, Hung C, Chen C, Lee H. Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer. Tumour Biol. 2017;39:1010428317694316 pubmed publisher
Wang L, Chiou S, Chai C, Hsi E, Chiang C, Huang S, et al. Transcription factor SPZ1 promotes TWIST-mediated epithelial-mesenchymal transition and oncogenesis in human liver cancer. Oncogene. 2017;36:4405-4414 pubmed publisher
Chao W, Deng J, Li P, Liang Y, Huang G. 3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFκB Signaling Pathways. Molecules. 2017;22: pubmed publisher
Kuo Y, Chen C, Wu P, Wu C, Sung P, Lin C, et al. N-(4-methoxyphenyl) caffeamide-induced melanogenesis inhibition mechanisms. BMC Complement Altern Med. 2017;17:71 pubmed publisher
Chen P, Shen W, Shih C, Ho K, Cheng C, Lin C, et al. The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity. Neuropharmacology. 2017;116:300-314 pubmed publisher
Hsieh C, Lee L, Leong W, Yang T, Yao C, Fang K. A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells. Drug Des Devel Ther. 2016;10:2947-2957 pubmed
Chen P, Chang C, Shih C, Cheng C, Lin C, Lee C, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016;110:362-375 pubmed publisher
Chen C, Lin M, Liang C, Wang S. The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages. PLoS ONE. 2016;11:e0158662 pubmed publisher
Lin C, Lee H, Lee M, Pan S, Ke C, Chiu A, et al. Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher
Xu Y, Wu D, Zheng W, Yu F, Yang F, Yao Y, et al. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. 2016;7:6146-58 pubmed publisher
Vallejo Flores G, Torres J, Sandoval Montes C, Arévalo Romero H, Meza I, Camorlinga Ponce M, et al. Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. Biomed Res Int. 2015;2015:761501 pubmed publisher
product information
Catalog Number :
GTX121937
Product Name :
AKT antibody [N3C2], Internal
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary Antibody
list of Pubmed id :
23832667,25061500,25130770,25788520,25914533,26557697,26561783,26369804,27231905,27487563,27414646,27695292,27986595,28114924,26196246,25686830,25362349,28378642,28368406,28350337,28345588,28499253,28612231,28597147,28741092,24457964,29215705,29142215,29512708,26716417,29642438
Background :
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
company information
GeneTex
2456 Alton Pkwy
Irvine, CA92606
info@genetex.com
http://www.genetex.com
1-877-436-3839
headquarters: USA