HMGB1 antibody [HAP46.5] | GeneTex GTX12029 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

HMGB1 antibody [HAP46.5]

catalog :

GTX12029

quantity :

100.00μl

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HAP46.5

reactivity :

human, dog, chicken

application :

western blot, ELISA

citations: 3

Reference
Sun L, Ishida T, Yasuda T, Kojima Y, Honjo T, Yamamoto Y, et al. RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice. Cardiovasc Res. 2009;82:371-81 pubmed publisher
Prasad R, Williams J, Hou E, Wilson S. Pol β associated complex and base excision repair factors in mouse fibroblasts. Nucleic Acids Res. 2012;40:11571-82 pubmed publisher
Yang J, Takahashi Y, Cheng E, Liu J, Terranova P, Zhao B, et al. GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death. J Cell Sci. 2010;123:861-70 pubmed publisher

product information

Catalog No :

GTX12029

Product Name :

HMGB1 antibody [HAP46.5]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

299 USD

list of Pubmed id :

19176597,23042675,20159967

Clone :

HAP46.5

Isotype :

IgG1

Product Description :

Mouse monoclonal [HAP46.5] to HMGB1

CrossReactivity :

Hu, Ms, Chk, Dog, Rat

Background :

HMG1 and HMG2, chromatin non-histone high mobility group proteins 1 and 2, are 27 and 25 kDa members of a family of proteins containing multiple HMG-boxes, conserved domains of 80 amino acids which mediate DNA binding of many proteins. HMG box domains recognize DNA structure, such as prebent, supercoiled or four way junction DNA, and non- specific DNA sequences. Both HMG1 and HMG2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMG1/2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites, such as steroid hormone receptors, p53, and Oct. HMG1/2 may serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription and replication.

Immunogen :

Recombinant full length protein (Human).

Buffer :

Preservative: 15mM Sodium Azide; Constituents: 0.01M PBS. pH 7.4

Uses :

ELISA, WB

Concentration :

1.9mg/ml

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.