Rad50 antibody [N1N2], N-term | GeneTex GTX119731 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Rad50 antibody [N1N2], N-term

catalog :

GTX119731

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

citations: 1

Reference
Heiser K, Nicholas C, Garcea R. Activation of DNA damage repair pathways by murine polyomavirus. Virology. 2016;497:346-356 pubmed publisher

product information

Catalog Number :

GTX119731

Product Name :

Rad50 antibody [N1N2], N-term

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary Antibody

list of Pubmed id :

27529739

Background :

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]