beta Catenin (phospho Ser33/Ser37) antibody [BC-22] | GeneTex GTX11350 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

beta Catenin (phospho Ser33/Ser37) antibody [BC-22]

catalog :

GTX11350

quantity :

50.00μl

price :

289 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

BC-22

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

Catalog No :

GTX11350

Product Name :

beta Catenin (phospho Ser33/Ser37) antibody [BC-22]

Host Species :

Mouse

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

50.00μl

List Price :

289 USD

Clone :

BC-22

Isotype :

IgG2b

Product Description :

Mouse monoclonal antibody [BC-22] to beta Catenin (phospho Ser33/Ser37)

CrossReactivity :

Hu, Ms, Rat

Background :

The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Immunogen :

Synthetic peptide: DS p GIHS p GATTTAPS conjugated to KLH, corresponding to amino acids 32-45 of Human beta Catenin.

Specificity :

Monoclonal Anti-phospho-beta-Catenin (pSer 33 /pSer 37 ) reacts specifically with beta-catenin phosphorylated at Ser 37 , and Ser 33 . At the peptide level, the antibody is inhibited more efficiently by the pSer 37<

Buffer :

Preservative: 15mM Sodium Azide; Constituents: 0.01M PBS. pH 7.4

Uses :

ELISA, WB

Concentration :

2.2mg/ml

General References :

Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.