beta III Tubulin antibody [SDL.3D10] | GeneTex GTX11314 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

beta III Tubulin antibody [SDL.3D10]

catalog :

GTX11314

quantity :

100.00μl

price :

259 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SDL.3D10

reactivity :

human, rat, cow

application :

western blot, ELISA, immunocytochemistry

product information

Catalog No :

GTX11314

Product Name :

beta III Tubulin antibody [SDL.3D10]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

259 USD

Clone :

SDL.3D10

Isotype :

IgG2b

Product Description :

Mouse monoclonal antibody [SDL.3D10] to beta III Tubulin

CrossReactivity :

Hu, Cow, Rat

Background :

Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and the cytoskeleton. Except in the simplest eukaryotes, tubulin exists in all cells as a mixture of similar, but not identical, sets of alpha and beta tubulin polypeptides. Within either set of polypeptides, individual subunits diverge from each other (both within and across species) at less than 10% of the amino acid positions. The most extreme diversity is localized to the 15 residues of the carboxy-terminal. For beta-tubulin five evolutionarily conserved isotype clones have been identified. These are almost totally conserved in the subunits utilized in the same cell types of different species, with the exception of the hematopoietic beta- tubulin which is the most highly divergent in sequence and is not conserved between species. Research has been centered around the hypothesis that these beta tubulin isotypes contribute to unique functional properties. It has been reported that the different isotypes of tubulin differ from each other in their ability to polymerize into microtubules. The monoclonal antibody from hybridoma SDL.3D10 can stimulate microtubule assembly when reconstituted with tubulin, tau or MAP2.

Immunogen :

Chemically synthesized peptide corresponding to the carboxyl-terminal sequence of human beta-tubulin isotype III conjugated to BSA.

Specificity :

GTX11314 may be used for the localization of isotype III of beta-tubulin using various immunochemical assays.

Buffer :

Preservative: 15mM Sodium Azide; Constituents: Raw Ascites

Uses :

ELISA, ICC/IF, WB, IB

General References :

Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles