Caspase 8 antibody | GeneTex GTX110723 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Caspase 8 antibody

catalog :

GTX110723

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

citations: 4

Reference
Xiong H, Yang Y, Yang K, Zhao D, Tang H, Ran X. Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer. Int J Oncol. 2018;52:279-287 pubmed publisher
Lin C, Chang T, Hsieh W, Hung M, Lin I, Lai S, et al. Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells. Cell Death Discov. 2016;2:16065 pubmed
Chen P, Chang C, Shih C, Cheng C, Lin C, Lee C, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016;110:362-375 pubmed publisher
Liu C, Hsu Y, Chien Y, Cha T, Tsao C. Dietary resistant maltodextrin ameliorates testicular function and spermatogenesis in streptozotocin-nicotinamide-induced diabetic rats. Andrologia. 2016;48:363-73 pubmed publisher

product information

Catalog Number :

GTX110723

Product Name :

Caspase 8 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary Antibody

list of Pubmed id :

21632856,25040912,26190442,27487563,27752362,29115399

Background :

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq]