VEGFR-2 antibody | GeneTex GTX10972 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

VEGFR-2 antibody

catalog :

GTX10972

quantity :

25.00μg

price :

289 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, neutralization

product information

Catalog No :

GTX10972

Product Name :

VEGFR-2 antibody

Host Species :

Goat

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

25.00μg

List Price :

289 USD

Isotype :

IgG

Product Description :

Goat polyclonal antibody to VEGFR-2

CrossReactivity :

Hu, Ms

Background :

Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, and increase vascular permeability in both large and small vessels. The mitogenic activity of VEGFs appears to be mediated by specific VEGF receptors. Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, KDR, Flk1) is one of the five receptor tyrosine kinases (RTKs) (VEGF Receptor 1/Flt1, VEGF Receptor 2/KDR/Flk1, VEGF Receptor 3/Flt4, tie1 and tek/tie2) whose expression is almost exclusively restricted to endothelial cells. These RTKs play central roles in vasculogenesis and angiogenesis. Tie1 and tek/tie2 are a class of RTKs containing two immunoglobulin-like domains, three EGF homology domains and three fibronectin type III domains in their extracellular regions. VEGF Receptor 1/Flt1, VEGF Receptor 2/KDR/Flk1, and VEGF Receptor 3/Flt4 are members of the class III subfamily of RTKs containing seven immunoglobulin-like repeats in their extracellular domains. VEGF Receptor 1 and VEGF Receptor 2 are both expressed in an endothelial cell-specific manner. They are detectable in virtually all tissues in adults and embryos. Monocytes express VEGF Receptor 1 and VEGF Receptor 2. VEGF Receptor 2 is also expressed in pancreatic duct cells, hematopoietic stem cells, megakaryocytes, specific tumor cell types such as malignant melanoma cells, and retinal progenitor cells. In the retina, two functional VEGF Receptor 2 forms are expressed as a result of alternative splicing. VEGF Receptor 2 is a key marker for pluripotent hematopoietic stem cells. VEGF Receptor 1 and VEGF Receptor 2 are closely related in their putative roles in angiogenesis. VEGF Receptor 2 is involved in commitment of endothelial-cell lineages and to cell proliferation, while VEGF Receptor 1 seems to be responsible for guiding endothelial cells into the proper spatial organization of the lumen-containing vessels. VEGF Receptor 1 binds both PIGF and VEGF with high affinity, whereas VEGF Receptor 2 binds VEGF with high affinity but does not bind PIGF. Recombinant soluble VEGF Receptor 2/Fc chimera binds VEGF with high affinity and is a potent VEGF antagonist.

Immunogen :

Recombinant extracellular domain (Mouse) expressed in mouse NSO cells.

Specificity :

Based on immunoblotting and ELISA, this antibody shows approximately 2% cross-reactivity with recombinant mouse VEGF Receptor 1, and no cross-reactivity with recombinant human VEGF Receptor 1 and VEGF Receptor 3.

Buffer :

Preservative: 15mM sodium azide.Constituents: 0.01M PBS, 1% BSA. pH 7.4

Uses :

ELISA, IHC, Neut, WB

Concentration :

0.1mg/ml