EGFR antibody [29.1] | GeneTex GTX10414 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

EGFR antibody [29.1]

catalog :

GTX10414

quantity :

100.00μl

price :

259 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

29.1

reactivity :

human, mouse, rat, dog

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

Catalog No :

GTX10414

Product Name :

EGFR antibody [29.1]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

259 USD

Clone :

29.1

Isotype :

IgG1

Product Description :

Mouse monoclonal [29.1] to EGFR

CrossReactivity :

Hu, Ms, Dog, Pig, Rat

Background :

The receptor for Epidermal Growth Factor is an integral cell membrane protein of 170 kDa, which spans the membranes of a wide range of normal and malignant epithelial cells. It is a tyrosine-specific protein kinase with the capacity to phosphorylate tyrosine residues located near its carboxy-terminus. EGF-R has anextracellular region which binds EGF and consequently mediates the initial response of cells to EGF and an intra- cellular region which posseses the tyrosine kinase activity. As a result of EGF binding to its specific receptor, there is increased DNA synthesis as well as other events such as cell proliferation, differentiationand repair of damaged epithelial tissue. The EGF-R has a half-life of approximately 10 hours in human fibroblasts, but in the presence of EGF this value is reduced to about 1 hour. A close similarity has been found between the sequence of the v-erb-B oncogene and the cytoplasmic and transmembrane part of the EGF-R (truncated EGF-R). It is hypothesized that an inappropriate activation of the human erb-B gene either by truncation or overexpression plays a role in the development of the malignancy. This hypothesis is supported by studies which have shown an increased number of EGF-R in various malignant tumors. High levels of EGF-R have been identified in sarcomas, gliomas, gynecological, breast, bladder and lungtumors.

Immunogen :

Tissue / cell preparation (Human A431 cell line).

Buffer :

Preservative: 0.1% Sodium Azide

Uses :

Apuri, ELISA, ICC/IF, IHC, IP, WB

Concentration :

9.4mg/ml

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.