tPA antibody | GeneTex GTX103453 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

tPA antibody

catalog :

GTX103453

quantity :

100.00μl

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; fig 5b	Svalina M, Kikuchi K, Abraham J, Lal S, Davare M, Settelmeyer T, et al. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. Sci Rep. 2016;6:27012 pubmed publisher

product information

Catalog No :

GTX103453

Product Name :

tPA antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

100.00μl

Product Description :

Rabbit Polyclonal antibody to tPA (plasminogen activator, tissue)

CrossReactivity :

Hu, Ms, Rat

Background :

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Immunogen :

Recombinant protein encompassing a sequence within the center region of human tPA. The exact sequence is proprietary.

Buffer :

1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Uses :

IHC-P, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Image Legend_4 :

tPA antibody detects PLAT protein by Western blot analysis. A. 30 µg PC-12 whole cell lysate/extract 7.5 % SDS-PAGE tPA antibody (GTX103453) dilution: 1:1000

Image Legend_5 :

tPA antibody detects tPA protein at cytoplasm on colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. tPA antibody (GTX103453) dilution: 1:250.