NFkB p65 antibody | GeneTex GTX102090 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

NFkB p65 antibody

catalog :

GTX102090

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

citations: 20

Reference
Wang Y, Zhu S, Wei W, Tu Y, Chen C, Song J, et al. Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice. Aging (Albany NY). 2020;12:20184-20197 pubmed publisher
Chen S, Kuo T, Liao Y, Lin M, Tien Y, Huang M. Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway. Oncogene. 2018;37:6041-6053 pubmed publisher
Gerzanich V, Kwon M, Woo S, Ivanov A, Simard J. SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells. PLoS ONE. 2018;13:e0195526 pubmed publisher
Ricci C, Ruscica M, Camera M, Rossetti L, Macchi C, Colciago A, et al. PCSK9 induces a pro-inflammatory response in macrophages. Sci Rep. 2018;8:2267 pubmed publisher
Wyss J, Kumar R, Mikulic J, Schneider M, Aebi J, Juillerat Jeanneret L, et al. Targeted Î³-secretase inhibition of Notch signaling activation in acute renal injury. Am J Physiol Renal Physiol. 2018;314:F736-F746 pubmed publisher
Tsai C, Tzeng S, Hsieh S, Yang Y, Hsiao Y, Tsai M, et al. A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer. Sci Rep. 2017;7:15624 pubmed publisher
Chamard Jovenin C, Thiebaut C, Chesnel A, Bresso E, Morel C, Smail Tabbone M, et al. Low-Dose Alkylphenol Exposure Promotes Mammary Epithelium Alterations and Transgenerational Developmental Defects, But Does Not Enhance Tumorigenic Behavior of Breast Cancer Cells. Front Endocrinol (Lausanne). 2017;8:272 pubmed publisher
Menicacci B, Cipriani C, Margheri F, Mocali A, Giovannelli L. Modulation of the Senescence-Associated Inflammatory Phenotype in Human Fibroblasts by Olive Phenols. Int J Mol Sci. 2017;18: pubmed publisher
Mahajan S, Aalinkeel R, Parikh N, Jacob A, Cwiklinski K, Sandhu P, et al. Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity. Immunol Invest. 2017;46:816-832 pubmed publisher
Sharma R, Cwiklinski K, Aalinkeel R, Reynolds J, Sykes D, Quaye E, et al. Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic. Immunol Invest. 2017;46:833-846 pubmed publisher
Wu P, Lyu J, Liu Y, Chien T, Hsu H, Wen K, et al. Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice. Int J Mol Sci. 2017;18: pubmed publisher
Andreucci E, Peppicelli S, Carta F, Brisotto G, Biscontin E, Ruzzolini J, et al. Carbonic anhydrase IX inhibition affects viability of cancer cells adapted to extracellular acidosis. J Mol Med (Berl). 2017;95:1341-1353 pubmed publisher
Gerzanich V, Makar T, Guda P, Kwon M, Stokum J, Woo S, et al. Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis. J Neuroinflammation. 2017;14:177 pubmed publisher
Huang Y, Tsai M, Hsieh P, Shih J, Wang T, Wang Y, et al. Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling. Toxicol Appl Pharmacol. 2017;329:128-139 pubmed publisher
Liu M, Chen W, Chiou C, Lo W, Dubey N, Chen Y, et al. Inhibition of chronic prostate inflammation by hyaluronic acid through an immortalized human prostate stromal cell line model. PLoS ONE. 2017;12:e0178152 pubmed publisher
Kuo C, Lin C, Hsu T. VHL Inactivation in Precancerous Kidney Cells Induces an Inflammatory Response via ER Stress-Activated IRE1Î± Signaling. Cancer Res. 2017;77:3406-3416 pubmed publisher
Thiebaut C, Chamard Jovenin C, Chesnel A, Morel C, Djermoune E, Boukhobza T, et al. Mammary epithelial cell phenotype disruption in vitro and in vivo through ERalpha36 overexpression. PLoS ONE. 2017;12:e0173931 pubmed publisher
Leu J, Chen M, Chang S, Yu S, Lin C, Wang H, et al. SP110b Controls Host Immunity and Susceptibility to Tuberculosis. Am J Respir Crit Care Med. 2017;195:369-382 pubmed publisher
Chen W, Lin C, Huang C, Hsu W, Lee C, Ou K, et al. Functional Recovery in Osteoarthritic Chondrocytes Through Hyaluronic Acid and Platelet-Rich Plasma-Inhibited Infrapatellar Fat Pad Adipocytes. Am J Sports Med. 2016;44:2696-2705 pubmed
Raninga P, Di Trapani G, Vuckovic S, Tonissen K. TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-ÐºÎ² inhibition. Cell Cycle. 2016;15:559-72 pubmed publisher

product information

Catalog Number :

GTX102090

Product Name :

NFkB p65 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary Antibody

list of Pubmed id :

25732306,26133168,26743692,27400716,27858493,28301550,28558962,28558037,28533271,28865458,24039598,28971991,28929255,28994699,29109696,29084133,29058550,29058549,29142311,29396513,29617457

Background :

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]