This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneCopoeia
product type :
protein
product name :
Human CAPN3 protein
catalog :
hRP-T2814-EF012
quantity :
100 ug
price :
765 USD
product information
Catalog :
hRP-T2814-EF012
volumne :
100 ug
symbol :
CAPN3
Name :
Human CAPN3 protein
description :
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controllingprogression through the cell cycle, regulation of gene expression, substrate degradation in some apoptoticpathways, and an involvement in long-term potentiation. Perturbations in calpain activity have beenassociated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).
GenBank Accession :
BC003521.1
Uniprot Accession :
Q9BQC8
application :
WB, ELISA, IP, antibody production, protein array
Fusion tag :
N-His
Peptide Length :
171aa(including fusion tag)
Molecular Weight :
20.2kDa(including fusion tag)
pI :
7
price :
765 USD
company information
GeneCopoeia
9620 Medical Center Drive
Rockville, MD 20850
inquiry@genecopoeia.com
www.genecopoeia.com
1-301-762-0888
headquarters: USA
GeneCopoeia offers the largest collection of expression-ready ORF cDNA, shRNA and miRNA clones. Available in a wide collection of lentiviral and non-viral expression vectors with a variety of fusion tags and reporters including fluorescent, solubility, purification and multi-functional tags. Explore the fully sequenced and expression-ready clone collections here.

Pre-validated gene-specific and miRNA qPCR primers are also available with reaction master mix reagents for quantitative analyses of gene or miRNA specific expression. SYBR Green® based qPCR mix kits together with pre-validated primers provide universal qPCR reaction conditions and robust qPCR data. Learn more about qPCR mix and primers.

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