This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneCopoeia
product type :
protein
product name :
Human cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
catalog :
hRP-T1759-EF011
quantity :
25 ug
price :
145 USD
product information
Catalog :
hRP-T1759-EF011
volumne :
25 ug
symbol :
CDKN2A
Name :
Human cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
description :
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
GenBank Accession :
NM_000077.2
Uniprot Accession :
P42771
application :
WB, ELISA, IP, antibody production, protein array
Fusion tag :
N-His
Peptide Length :
171aa(including fusion tag)
Molecular Weight :
18.4kDa(including fusion tag)
pI :
6.6
price :
145 USD
company information
GeneCopoeia
9620 Medical Center Drive
Rockville, MD 20850
inquiry@genecopoeia.com
www.genecopoeia.com
1-301-762-0888
headquarters: USA
GeneCopoeia offers the largest collection of expression-ready ORF cDNA, shRNA and miRNA clones. Available in a wide collection of lentiviral and non-viral expression vectors with a variety of fusion tags and reporters including fluorescent, solubility, purification and multi-functional tags. Explore the fully sequenced and expression-ready clone collections here.

Pre-validated gene-specific and miRNA qPCR primers are also available with reaction master mix reagents for quantitative analyses of gene or miRNA specific expression. SYBR Green® based qPCR mix kits together with pre-validated primers provide universal qPCR reaction conditions and robust qPCR data. Learn more about qPCR mix and primers.

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