This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneCopoeia
product type :
protein
product name :
Human 26S proteasome non-ATPase regulatory subunit 10
catalog :
hRP-Q0214-EF011
quantity :
25 ug
price :
145 USD
product information
Catalog :
hRP-Q0214-EF011
volumne :
25 ug
symbol :
PSMD10
Name :
Human 26S proteasome non-ATPase regulatory subunit 10
description :
26S proteasome non-ATPase regulatory subunit 10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. This protein acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. It regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. The protein is involved in p53-independent apoptosis. 26S proteasome non-ATPase regulatory subunit 10 is involved in regulation of NF-kappa-B by retaining it in the cytoplasm. This protein binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
GenBank Accession :
NM_002814.1
Uniprot Accession :
O75832
application :
WB, ELISA, IP, antibody production, protein array
Fusion tag :
N-His
Peptide Length :
241aa(including fusion tag)
Molecular Weight :
26.4kDa(including fusion tag)
pI :
6.6
price :
145 USD
company information
GeneCopoeia
9620 Medical Center Drive
Rockville, MD 20850
inquiry@genecopoeia.com
www.genecopoeia.com
1-301-762-0888
headquarters: USA
GeneCopoeia offers the largest collection of expression-ready ORF cDNA, shRNA and miRNA clones. Available in a wide collection of lentiviral and non-viral expression vectors with a variety of fusion tags and reporters including fluorescent, solubility, purification and multi-functional tags. Explore the fully sequenced and expression-ready clone collections here.

Pre-validated gene-specific and miRNA qPCR primers are also available with reaction master mix reagents for quantitative analyses of gene or miRNA specific expression. SYBR Green® based qPCR mix kits together with pre-validated primers provide universal qPCR reaction conditions and robust qPCR data. Learn more about qPCR mix and primers.

Save time and publish faster on the GeneCopoeia Expressway to Discovery& number 8482;.