CDK12 Polyclonal Antibody | Epigentek A70299-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

CDK12 Polyclonal Antibody

catalog :

A70299-100

quantity :

100 μl

price :

411.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

western blot, ELISA

more info or order :

Epigentek product webpage

product information

Catalog# :

A70299

Part # :

A70299-100

2022 Price (US) :

411.00 USD

Product Description (Product Name) :

CDK12 Polyclonal Antibody

Size :

100 μl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

CDK12

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human

Applications :

ELISA, WB; Recommended dilution: WB: 1:500-1:5000

Isotype :

IgG

Immunogen :

Recombinant Human Cyclin-dependent kinase 12 protein (1309-1490AA)

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Uniprot ID :

Q9NYV4

Gene :

CDK12

Storage Buffer :

0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4

Purity :

Protein G purified

Alternative Names :

Cyclin-dependent kinase 12, Cdc2-related kinase, arginine/serine-rich, CrkRS, Cell division cycle 2-related protein kinase 7, CDC2-related protein kinase 7, Cell division protein kinase 12, hCDK12, CDK12, CRK7, CRKRS, KIAA0904

Background :

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

more info or order :

Epigentek product webpage