CD163 Monoclonal Antibody [RMC238A] | Epigentek A68443-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

CD163 Monoclonal Antibody [RMC238A]

catalog :

A68443-100

quantity :

100 µl

price :

411.00 USD

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RMC238A

reactivity :

human

application :

ELISA, immunohistochemistry, flow cytometry

more info or order :

Epigentek product webpage

product information

Catalog# :

A68443

Part # :

A68443-100

2022 Price (US) :

411.00 USD

Product Description (Product Name) :

CD163 Monoclonal Antibody [RMC238A]

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

CD163

Conjugate :

Unconjugated

Clonality :

Monoclonal

Clone :

RMC238A

Species/Reactivity :

Human

Applications :

ELISA, IHC, FC; Recommended dilution: IHC: 1:50-1:500

Isotype :

IgG

Immunogen :

A synthesized peptide

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Uniprot ID :

Q86VB7

Gene :

CD163

Storage Buffer :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity :

Affinity Purified

Alternative Names :

Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor, CD163, Soluble CD163, sCD163, CD163, M130

Background :

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

more info or order :

Epigentek product webpage