antibody

HDAC3 Polyclonal Antibody

A68305-100

100 µl

370.00 USD

polyclonal

domestic rabbit

nonconjugated

polyclonal

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation

A68305-100

370.00 USD

HDAC3 Polyclonal Antibody

100 µl

Rabbit

Histone deacetylase 3

Unconjugated

Polyclonal

Human, Mouse

ELISA, WB, IHC, IF, ChIP; Recommended dilution:WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

IgG

Recombinant Human Histone deacetylase 3 protein (1-428AA)

Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

O15379

HDAC3

0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4

Protein G purified

HD3, RPD3-2, SMAP45, HDAC3

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.