HDAC1 Polyclonal Antibody | Epigentek A68304-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

HDAC1 Polyclonal Antibody

catalog :

A68304-100

quantity :

100 µl

price :

370.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human

application :

ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation

more info or order :

Epigentek product webpage

product information

Catalog# :

A68304

Part # :

A68304-100

2022 Price (US) :

370.00 USD

Product Description (Product Name) :

HDAC1 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

HDAC1

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human

Applications :

ELISA, IHC, IF, ChIP; Recommended dilution: IHC:1:20-1:200, IF:1:100-1:500

Isotype :

IgG

Immunogen :

Recombinant Human Histone deacetylase 1 protein (1-482AA)

Shipping Temp :

Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Uniprot ID :

Q13547

Gene :

HDAC1

Storage Buffer :

0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.

Purity :

Protein G purified

Alternative Names :

Histone deacetylase 1, HD1, HDAC1, RPD3L1

Background :

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

more info or order :

Epigentek product webpage