TDG Polyclonal Antibody | Epigentek A-6704-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

TDG Polyclonal Antibody

catalog :

A-6704-100

quantity :

100 µl

price :

479.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Epigentek product webpage

product information

Catalog# :

A-6704

Part # :

A-6704-100

2022 Price (US) :

479.00 USD

Product Description (Product Name) :

TDG Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

TDG

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Mouse, Rat

Applications :

WB; Recommended dilution: WB 1:500 - 1:2000

Isotype :

IgG

Immunogen :

Recombinant Protein of Human TDG

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

Q13569

Gene :

TDG

Storage Buffer :

Liquid. In PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3.

Purity :

Affinity Purified

Background :

Thymine DNA Glycosylase (TDG) is a nuclear protein that belongs to the TDG/mug DNA glycosylase family. TDG amends G/T mismatches to G/C pairs by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired thymine. In addition, TDG amends a subset of G/U mispairs inefficiently removed by the more abundant uracil glycosylases. Retinoic acid receptors interact with TDG physically and functionally, improving the capability of the retinoid X receptor and the retinoid X receptor/retinoid acid receptor complex to bind to their response elements. This protein's DNA substrate and AP site binding affinity is diminished when it interacts with SUMO-1 and SUMO-2/3, two ubiquitin-like proteins that also covalently modify TDG. This sumoylation correlates with a substantial rise in enzymatic turnover in reactions with a G/U substrate and the shortage of G/T processing activity.

more info or order :

Epigentek product webpage