HDAC2 Polyclonal Antibody | Epigentek A-4709-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

HDAC2 Polyclonal Antibody

catalog :

A-4709-100

quantity :

100 µl

price :

446.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Epigentek product webpage

product information

Catalog# :

A-4709

Part # :

A-4709-100

2022 Price (US) :

446.00 USD

Product Description (Product Name) :

HDAC2 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

HDAC2

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Mouse, Rat, Human

Applications :

WB, IHC; Recommended dilution: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Isotype :

IgG

Citations :

33245480

Immunogen :

Recombinant fusion protein containing a sequence corresponding to amino acids 429-488 of human HDAC2 (NP_001518.3).

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

Q92769

Gene :

HDAC2

Storage Buffer :

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purified

Alternative Names :

D10Wsu179e antibody, HD 2 antibody, Histone deacetylase 2 (HD2) antibody, OTTHUMP00000017046 antibody, OTTHUMP00000227077 antibody, OTTHUMP00000227078 antibody, RPD3 antibody, transcriptional regulator homolog RPD3 antibody, YAF1 antibody, YY1 associated factor 1 antibody, Yy1bp antibody

Background :

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large mµltiprotein complexes has yielded important insights into how these enzymes regµlate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, sµggesting mµltiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).HDAC1 and HDAC2 are highly homologous and are involved in histone deacetylation, chromatin remodeling and transcriptional repression (8-10). Both proteins are found together in numerous complexes including the nucleosome remodeling and deacetylation complex (NuRD), MeCP1, and the mSin3A corepressor complex.

more info or order :

Epigentek product webpage