SIRT6 Polyclonal Antibody | Epigentek A-4705-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

SIRT6 Polyclonal Antibody

catalog :

A-4705-100

quantity :

100 µl

price :

479.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse

application :

western blot

more info or order :

Epigentek product webpage

product information

Catalog# :

A-4705

Part # :

A-4705-100

2022 Price (US) :

479.00 USD

Product Description (Product Name) :

SIRT6 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

SIRT6

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse

Applications :

WB; Recommended dilution: WB (1:500 - 1:2000)

Isotype :

IgG

Immunogen :

Synthetic Peptide of Mouse SIRT6

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid repeated freeze.

Uniprot ID :

Q8N6T7

Gene :

SIRT6

Storage Buffer :

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purity :

Affinity Purified

Alternative Names :

SIR2L6

Background :

SIRT6 (sirtuin 6) is a protein coding gene that belongs to the sirtuin family. Sirtuns are a highly conserved NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and aging. This protein has deacetylase activity towards Lys9 and Lys56 of histone H3. During the S-phase of the cell cycle, SIRT6 regulates acetylation of histone H3 in telomeric chromatin. It also deacetylates Lys9 of histone H3 at NF-kappa-B target promoters and can down-regulate the expression of a subset of NF-kappa-B target genes. SIRT6 is thought to be involved in normal telomere maintenance and in WRN (the factor that is mutated in Werner syndrome) with telomeres during S-phase. SIRT6 is required for genomic stability, normal IGF1 serum levels, and normal glucose homeostasis. It also regulates cellular senescence and apoptosis and the production of TNF protein. SIRT6 directly represses multiple glycolytic genes and functions as a corepressor of the transcription factor Hif1alpha. A shortage of SIRT6 increases glycolysis and lessens mitochondrial respiration. SIRT6 has a main role in regulating glucose homeostasis.

more info or order :

Epigentek product webpage