SIRT1 Polyclonal Antibody | Epigentek A-4700-100 product information

product summary

company name :

Epigentek

product type :

antibody

product name :

SIRT1 Polyclonal Antibody

catalog :

A-4700-100

quantity :

100 µl

price :

308.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

polyclonal

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Epigentek product webpage

citations: 1

Reference
Heo J, Lim J, Lee S, Jeong J, Kang H, Kim Y, et al. Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l. Cell Rep. 2017;18:1930-1945 pubmed publisher

product information

Catalog# :

A-4700

Part # :

A-4700-100

2022 Price (US) :

308.00 USD

Product Description (Product Name) :

SIRT1 Polyclonal Antibody

Size :

100 µl

Host :

Rabbit

Antigen (Uniprot Accession, Gene or prot ... :

SIRT1

Conjugate :

Unconjugated

Clonality :

Polyclonal

Species/Reactivity :

Human, Mouse, Rat

Applications :

WB, IF; Recommended dilution: WB: 1:500-1:2000, IF:1:50-1:200

Isotype :

IgG

Citations :

28228259

Immunogen :

A synthetic peptide of human SIRT1

Shipping Temp :

Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Uniprot ID :

Q96EB6

Gene :

SIRT1

Storage Buffer :

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity :

Affinity Purification

Alternative Names :

SIRT1, SIR2L1

Background :

The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae SIR2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARgamma, and the PPARgamma coactivator-1alpha (PGC-1alpha) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. Deacetylation of PPARgamma and PGC-1alpha regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by phosphorylation, since it is phosphorylated on Ser27 and Ser47 in vivo, however, the function of these phosphorylation sites has not yet been determined.

more info or order :

Epigentek product webpage